Drug interactions
Colestipol + Piroxicam
Severity: Moderate
Colestipol and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colestipol is a bile acid sequestrant that binds oral drugs in the gut and can lower their absorption. Piroxicam undergoes enterohepatic recycling, so binding can reduce its absorption and shorten its half-life, reducing its effect.
What this interaction means in plain words
Colestipol and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colestipol belongs to Cardiovascular; Piroxicam belongs to Musculoskeletal.
Why it happens
Binding of piroxicam in the gastrointestinal tract by the resin, reducing absorption and interrupting enterohepatic recirculation.
What to do
Give piroxicam at least 1 hour before or 4 hours after colestipol, and monitor symptom control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Colestipol
- Amlodipine-hydrochlorothiazide-valsartan + Colestipol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Colestipol Moderate
- Atenolol-chlorthalidone + Colestipol Moderate
- Azilsartan-chlorthalidone + Colestipol Moderate
- Candesartan-hydrochlorothiazide + Colestipol Moderate
- Captopril-hydrochlorothiazide + Colestipol Moderate
Frequently asked questions
Can I take Colestipol with Piroxicam?
MediHelp rates the interaction as moderate. Colestipol and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colestipol is a bile acid sequestrant that binds oral drugs in the gut and can lower their absorption. Piroxicam undergoes enterohepatic recycling, so binding can reduce its absorption and shorten its half-life, reducing its effect.
How serious is the interaction between Colestipol and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give piroxicam at least 1 hour before or 4 hours after colestipol, and monitor symptom control.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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