Drug interactions
Colistin + Oxaliplatin
Severity: Moderate
Colistin and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have potential renal toxicity, so co-administration may increase the risk of kidney injury. Oxaliplatin is less nephrotoxic than other platinum agents, but reduced clearance could worsen toxicity of either drug.
What this interaction means in plain words
Colistin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colistin belongs to Anti Bacterial; Oxaliplatin belongs to Oncology.
Why it happens
Additive nephrotoxicity; oxaliplatin and colistin are both renally eliminated and may injure renal tubules.
What to do
Monitor serum creatinine before each oxaliplatin cycle and during colistin therapy. Adjust doses to renal function and keep the patient well hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colistin
- Colistin + Polymyxin b Contraindicated
- Amikacin + Colistin Major
- Amphotericin b deoxycholate + Colistin Major
- Amphotericin b + Colistin Major
- Atracurium + Colistin Major
- Bacitracin + Colistin Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Colistin with Oxaliplatin?
MediHelp rates the interaction as moderate. Colistin and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have potential renal toxicity, so co-administration may increase the risk of kidney injury. Oxaliplatin is less nephrotoxic than other platinum agents, but reduced clearance could worsen toxicity of either drug.
How serious is the interaction between Colistin and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine before each oxaliplatin cycle and during colistin therapy. Adjust doses to renal function and keep the patient well hydrated.
What other medicines interact with Colistin?
MediHelp also lists interactions of Colistin with, for example, Polymyxin b, Amikacin, Amphotericin b deoxycholate. The full list is on the Colistin page.
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