Drug interactions
Conivaptan + Montelukast
Severity: Minor
Conivaptan and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and could increase montelukast concentrations. Because montelukast is tolerated over a broad exposure range, the effect is probably minor, and conivaptan is used short-term in hospital.
What this interaction means in plain words
Conivaptan and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Conivaptan inhibits CYP3A4, reducing a secondary pathway of montelukast metabolism.
What to do
No dose adjustment is generally needed. Monitor for adverse effects if both are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Frequently asked questions
Can I take Conivaptan with Montelukast?
MediHelp rates the interaction as minor. Conivaptan and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Conivaptan is a CYP3A4 inhibitor and could increase montelukast concentrations. Because montelukast is tolerated over a broad exposure range, the effect is probably minor, and conivaptan is used short-term in hospital.
How serious is the interaction between Conivaptan and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for adverse effects if both are used.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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