Drug interactions
Conjugated estrogens + Enzalutamide
Severity: Moderate
Conjugated estrogens and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may lower estrogen concentrations by inducing their metabolism. This can lead to reduced efficacy, such as return of menopausal symptoms or bleeding irregularities.
What this interaction means in plain words
Conjugated estrogens and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by enzalutamide increases the metabolism of estrogens.
What to do
Monitor for reduced estrogen effect and increase the estrogen dose based on clinical response if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Conjugated estrogens with Enzalutamide?
MediHelp rates the interaction as moderate. Conjugated estrogens and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide may lower estrogen concentrations by inducing their metabolism. This can lead to reduced efficacy, such as return of menopausal symptoms or bleeding irregularities.
How serious is the interaction between Conjugated estrogens and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced estrogen effect and increase the estrogen dose based on clinical response if needed.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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