Drug interactions
Conjugated estrogens + Posaconazole
Severity: Minor
Conjugated estrogens and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase conjugated estrogen levels through CYP3A4 inhibition. This can intensify estrogenic effects such as breast tenderness, nausea and uterine bleeding.
What this interaction means in plain words
Conjugated estrogens and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated estrogen metabolism by posaconazole.
What to do
Monitor for estrogenic adverse effects and reduce the estrogen dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Conjugated estrogens with Posaconazole?
MediHelp rates the interaction as minor. Conjugated estrogens and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole may increase conjugated estrogen levels through CYP3A4 inhibition. This can intensify estrogenic effects such as breast tenderness, nausea and uterine bleeding.
How serious is the interaction between Conjugated estrogens and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects and reduce the estrogen dose if they occur.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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