Drug interactions
Corticotropin + Dapagliflozin-metformin
Severity: Moderate
Corticotropin and Dapagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin stimulates cortisol release, which raises blood glucose and can cause marked hyperglycemia in diabetic patients. Antidiabetic therapy may need intensification during treatment.
What this interaction means in plain words
Corticotropin and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Dapagliflozin-metformin belongs to Endocrine.
Why it happens
Corticotropin-induced glucocorticoid excess increases gluconeogenesis and insulin resistance, opposing glucose-lowering therapy.
What to do
Monitor blood glucose frequently during corticotropin therapy and increase antidiabetic therapy as needed. Reduce doses again as treatment ends to avoid hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Corticotropin and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin stimulates cortisol release, which raises blood glucose and can cause marked hyperglycemia in diabetic patients. Antidiabetic therapy may need intensification during treatment.
How serious is the interaction between Corticotropin and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during corticotropin therapy and increase antidiabetic therapy as needed. Reduce doses again as treatment ends to avoid hypoglycemia.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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