Drug interactions
Corticotropin + Hydrochlorothiazide-losartan
Severity: Moderate
Corticotropin and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticotropin promotes mineralocorticoid-related potassium loss and may add to the hypokalemia caused by hydrochlorothiazide. Fluid retention from corticotropin may also oppose the antihypertensive effect.
What this interaction means in plain words
Corticotropin and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive renal potassium wasting through adrenal steroid stimulation plus thiazide-induced kaliuresis.
What to do
Monitor serum potassium and blood pressure during corticotropin treatment and supplement potassium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Corticotropin and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticotropin promotes mineralocorticoid-related potassium loss and may add to the hypokalemia caused by hydrochlorothiazide. Fluid retention from corticotropin may also oppose the antihypertensive effect.
How serious is the interaction between Corticotropin and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure during corticotropin treatment and supplement potassium if needed.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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