Drug interactions
Corticotropin + Levofloxacin
Severity: Moderate
Corticotropin and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones carry a boxed warning for tendinitis and tendon rupture, and corticosteroid exposure further raises that risk. Corticotropin stimulates endogenous cortisol release, so a similar increase in risk is expected, especially in older patients.
What this interaction means in plain words
Corticotropin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Corticotropin belongs to Endocrine; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive tendon toxicity: fluoroquinolone effects on tenocytes combined with glucocorticoid-mediated collagen and tendon weakening.
What to do
Counsel patients to stop levofloxacin and rest if tendon pain or swelling develops. Consider a non-fluoroquinolone antibiotic in older patients or those on prolonged corticotropin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Corticotropin
Frequently asked questions
Can I take Corticotropin with Levofloxacin?
MediHelp rates the interaction as moderate. Corticotropin and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones carry a boxed warning for tendinitis and tendon rupture, and corticosteroid exposure further raises that risk. Corticotropin stimulates endogenous cortisol release, so a similar increase in risk is expected, especially in older patients.
How serious is the interaction between Corticotropin and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to stop levofloxacin and rest if tendon pain or swelling develops. Consider a non-fluoroquinolone antibiotic in older patients or those on prolonged corticotropin.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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