Drug interactions
Cortisone + Posaconazole
Severity: Moderate
Cortisone and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may raise exposure to corticosteroids that are CYP3A4 substrates, and cortisone and its active form hydrocortisone are affected modestly. Prolonged co-use could cause signs of glucocorticoid excess such as fluid retention, hyperglycemia and Cushingoid features.
What this interaction means in plain words
Cortisone and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Posaconazole inhibits CYP3A4, reducing the metabolic clearance of cortisol and related corticosteroids.
What to do
Monitor blood glucose, blood pressure and signs of steroid excess during prolonged co-use. Reduce the corticosteroid dose if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cortisone and Posaconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Cortisone with Posaconazole?
MediHelp rates the interaction as moderate. Cortisone and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may raise exposure to corticosteroids that are CYP3A4 substrates, and cortisone and its active form hydrocortisone are affected modestly. Prolonged co-use could cause signs of glucocorticoid excess such as fluid retention, hyperglycemia and Cushingoid features.
How serious is the interaction between Cortisone and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, blood pressure and signs of steroid excess during prolonged co-use. Reduce the corticosteroid dose if effects emerge.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
