Drug interactions
Crizotinib + Elacestrant
Severity: Moderate
Crizotinib and Elacestrant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and may increase elacestrant plasma concentrations. Higher exposure could increase elacestrant adverse effects such as nausea and dyslipidemia.
What this interaction means in plain words
Crizotinib and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Elacestrant belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, the main enzyme metabolizing elacestrant.
What to do
Avoid concomitant use where possible. If used together, monitor for elacestrant adverse effects and consider an alternative to crizotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Crizotinib with Elacestrant?
MediHelp rates the interaction as moderate. Crizotinib and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and may increase elacestrant plasma concentrations. Higher exposure could increase elacestrant adverse effects such as nausea and dyslipidemia.
How serious is the interaction between Crizotinib and Elacestrant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible. If used together, monitor for elacestrant adverse effects and consider an alternative to crizotinib.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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