Drug interactions
Crizotinib + Eszopiclone
Severity: Moderate
Crizotinib and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and can raise eszopiclone concentrations, which increases sedation and next-day psychomotor impairment. Eszopiclone labeling advises a lower dose with strong CYP3A4 inhibitors, and caution is reasonable with moderate ones.
What this interaction means in plain words
Crizotinib and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Eszopiclone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 by crizotinib reduces the oxidative clearance of eszopiclone.
What to do
Start eszopiclone at 1 mg and increase cautiously only if needed. Counsel on next-day impairment and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Eszopiclone?
MediHelp rates the interaction as moderate. Crizotinib and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and can raise eszopiclone concentrations, which increases sedation and next-day psychomotor impairment. Eszopiclone labeling advises a lower dose with strong CYP3A4 inhibitors, and caution is reasonable with moderate ones.
How serious is the interaction between Crizotinib and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start eszopiclone at 1 mg and increase cautiously only if needed. Counsel on next-day impairment and driving.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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