Drug interactions
Crizotinib + Famotidine
Severity: Minor
Crizotinib and Famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib solubility is pH dependent and falls as pH rises, so acid suppression could theoretically lower its absorption. No formal study has shown a clinically meaningful loss of efficacy with H2 blockers.
What this interaction means in plain words
Crizotinib and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Famotidine belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH may reduce crizotinib solubility and bioavailability, though this is predicted rather than demonstrated.
What to do
No routine dose change is required with famotidine. Monitor for reduced tumour response if acid suppression is given long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Famotidine
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Famotidine?
MediHelp rates the interaction as minor. Crizotinib and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib solubility is pH dependent and falls as pH rises, so acid suppression could theoretically lower its absorption. No formal study has shown a clinically meaningful loss of efficacy with H2 blockers.
How serious is the interaction between Crizotinib and Famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required with famotidine. Monitor for reduced tumour response if acid suppression is given long term.
What other medicines interact with Famotidine?
MediHelp also lists interactions of Famotidine with, for example, Atazanavir, Dasatinib, Infigratinib. The full list is on the Famotidine page.
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