Drug interactions
Crizotinib + Fluticasone-vilanterol
Severity: Moderate
Crizotinib and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong the QT interval and cause bradycardia, and vilanterol may add tachycardia and hypokalemia. Crizotinib also inhibits CYP3A4, which may increase vilanterol and fluticasone exposure.
What this interaction means in plain words
Crizotinib and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation plus moderate CYP3A4 inhibition by crizotinib.
What to do
Monitor ECG and electrolytes at baseline and periodically during treatment. Watch for beta-agonist adverse effects such as tremor and palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Crizotinib and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib can prolong the QT interval and cause bradycardia, and vilanterol may add tachycardia and hypokalemia. Crizotinib also inhibits CYP3A4, which may increase vilanterol and fluticasone exposure.
How serious is the interaction between Crizotinib and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically during treatment. Watch for beta-agonist adverse effects such as tremor and palpitations.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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