Drug interactions
Crizotinib + Fostemsavir
Severity: Moderate
Crizotinib and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong the QT interval, and fostemsavir has been associated with QT prolongation at supratherapeutic doses. Combined use may add to the risk of arrhythmia, especially with electrolyte disturbances or heart disease. The risk at recommended fostemsavir doses is likely modest.
What this interaction means in plain words
Crizotinib and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Fostemsavir belongs to Anti Virals.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor ECG periodically, and correct potassium and magnesium abnormalities. Do not exceed the recommended fostemsavir dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Crizotinib with Fostemsavir?
MediHelp rates the interaction as moderate. Crizotinib and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib can prolong the QT interval, and fostemsavir has been associated with QT prolongation at supratherapeutic doses. Combined use may add to the risk of arrhythmia, especially with electrolyte disturbances or heart disease. The risk at recommended fostemsavir doses is likely modest.
How serious is the interaction between Crizotinib and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG periodically, and correct potassium and magnesium abnormalities. Do not exceed the recommended fostemsavir dose.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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