Drug interactions
Crizotinib + Guanfacine
Severity: Moderate
Crizotinib and Guanfacine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may raise guanfacine concentrations, causing hypotension, bradycardia and sedation. Crizotinib also causes bradycardia, so effects may be additive.
What this interaction means in plain words
Crizotinib and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Guanfacine belongs to Cardiovascular.
Why it happens
Crizotinib inhibits CYP3A4 metabolism of guanfacine, with additive bradycardic effects.
What to do
Consider halving the guanfacine dose (extended-release per labeling). Monitor heart rate and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Crizotinib with Guanfacine?
MediHelp rates the interaction as moderate. Crizotinib and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib may raise guanfacine concentrations, causing hypotension, bradycardia and sedation. Crizotinib also causes bradycardia, so effects may be additive.
How serious is the interaction between Crizotinib and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider halving the guanfacine dose (extended-release per labeling). Monitor heart rate and blood pressure.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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