Drug interactions
Crizotinib + Histrelin
Severity: Moderate
Crizotinib and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, produces androgen deprivation that can prolong the QT interval. With crizotinib, which also prolongs QT, the risk of torsades de pointes may be increased.
What this interaction means in plain words
Crizotinib and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Histrelin belongs to Musculoskeletal.
Why it happens
Additive QT prolongation; androgen deprivation and crizotinib each affect cardiac repolarization.
What to do
Monitor ECG and electrolytes at baseline and periodically, and correct hypokalemia and hypomagnesemia. Consider alternatives in patients with congenital long QT or other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Crizotinib with Histrelin?
MediHelp rates the interaction as moderate. Crizotinib and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, produces androgen deprivation that can prolong the QT interval. With crizotinib, which also prolongs QT, the risk of torsades de pointes may be increased.
How serious is the interaction between Crizotinib and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically, and correct hypokalemia and hypomagnesemia. Consider alternatives in patients with congenital long QT or other risk factors.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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