Drug interactions
Crizotinib + Imatinib
Severity: Moderate
Crizotinib and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are CYP3A4 substrates and inhibitors, so each may increase the other's exposure. This may increase adverse effects such as hepatotoxicity, edema, QT prolongation and bradycardia.
What this interaction means in plain words
Crizotinib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Imatinib belongs to Oncology.
Why it happens
Mutual inhibition of CYP3A4, with possible P-glycoprotein effects, reduces clearance of both drugs.
What to do
Monitor liver enzymes, ECG and heart rate, and for edema and cytopenias. Reduce doses if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Imatinib?
MediHelp rates the interaction as moderate. Crizotinib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are CYP3A4 substrates and inhibitors, so each may increase the other's exposure. This may increase adverse effects such as hepatotoxicity, edema, QT prolongation and bradycardia.
How serious is the interaction between Crizotinib and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes, ECG and heart rate, and for edema and cytopenias. Reduce doses if adverse effects develop.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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