Drug interactions
Crizotinib + Ipratropium-salbutamol
Severity: Moderate
Crizotinib and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong the QT interval and cause bradycardia. Salbutamol may add to QT effects, especially at high doses or with hypokalemia. The combination may increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Crizotinib and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with salbutamol-induced hypokalemia increasing susceptibility.
What to do
Monitor ECG and electrolytes, and correct potassium and magnesium abnormalities. Avoid excessive salbutamol doses during crizotinib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Crizotinib and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib can prolong the QT interval and cause bradycardia. Salbutamol may add to QT effects, especially at high doses or with hypokalemia. The combination may increase arrhythmia risk in susceptible patients.
How serious is the interaction between Crizotinib and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and correct potassium and magnesium abnormalities. Avoid excessive salbutamol doses during crizotinib therapy.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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