Drug interactions
Crizotinib + Isavuconazonium
Severity: Moderate
Crizotinib and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a CYP3A4 substrate and moderate inhibitor, and crizotinib may inhibit CYP3A to some extent, raising isavuconazole levels. Isavuconazole shortens QT, and isavuconazole may in turn raise crizotinib exposure.
What this interaction means in plain words
Crizotinib and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Isavuconazonium belongs to Anti Fungals.
Why it happens
Bidirectional CYP3A4 inhibition, with isavuconazole increasing crizotinib exposure and crizotinib reducing isavuconazole clearance.
What to do
Monitor for crizotinib toxicity including ECG and liver tests, and for isavuconazole adverse effects such as hepatic effects. Adjust crizotinib if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Crizotinib with Isavuconazonium?
MediHelp rates the interaction as moderate. Crizotinib and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole is a CYP3A4 substrate and moderate inhibitor, and crizotinib may inhibit CYP3A to some extent, raising isavuconazole levels. Isavuconazole shortens QT, and isavuconazole may in turn raise crizotinib exposure.
How serious is the interaction between Crizotinib and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for crizotinib toxicity including ECG and liver tests, and for isavuconazole adverse effects such as hepatic effects. Adjust crizotinib if toxicity occurs.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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