Drug interactions
Crizotinib + Lemborexant
Severity: Major
Crizotinib and Lemborexant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A inhibitor and can raise lemborexant exposure. This may increase somnolence, next-day impairment and other CNS effects.
What this interaction means in plain words
Crizotinib and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Lemborexant belongs to Central Nervous System.
Why it happens
Crizotinib inhibits CYP3A4-mediated metabolism of lemborexant.
What to do
Avoid the combination where possible. If it is necessary, limit lemborexant to the reduced maximum dose recommended in its labeling for moderate CYP3A inhibitors and monitor for daytime sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Crizotinib with Lemborexant?
MediHelp rates the interaction as major. Crizotinib and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib is a moderate CYP3A inhibitor and can raise lemborexant exposure. This may increase somnolence, next-day impairment and other CNS effects.
How serious is the interaction between Crizotinib and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is necessary, limit lemborexant to the reduced maximum dose recommended in its labeling for moderate CYP3A inhibitors and monitor for daytime sedation.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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