Drug interactions
Crizotinib + Lenacapavir
Severity: Moderate
Crizotinib and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may increase crizotinib concentrations, with effects persisting for months after the last subcutaneous dose. Higher crizotinib exposure raises the risk of QT prolongation, hepatotoxicity and bradycardia.
What this interaction means in plain words
Crizotinib and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Lenacapavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by lenacapavir reduces crizotinib metabolism.
What to do
Monitor ECG, heart rate and liver tests, and consider crizotinib dose reduction if adverse effects emerge. Remember the inhibitory effect may persist long after lenacapavir dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Crizotinib with Lenacapavir?
MediHelp rates the interaction as moderate. Crizotinib and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may increase crizotinib concentrations, with effects persisting for months after the last subcutaneous dose. Higher crizotinib exposure raises the risk of QT prolongation, hepatotoxicity and bradycardia.
How serious is the interaction between Crizotinib and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and liver tests, and consider crizotinib dose reduction if adverse effects emerge. Remember the inhibitory effect may persist long after lenacapavir dosing.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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