Drug interactions
Crizotinib + Maprotiline
Severity: Major
Crizotinib and Maprotiline: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes and other serious ventricular arrhythmias. Risk is greater with bradycardia, hypokalemia, hypomagnesemia or underlying heart disease. Crizotinib can also cause bradycardia, which further adds to arrhythmic risk.
What this interaction means in plain words
Crizotinib and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Maprotiline belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization through effects on cardiac ion channels.
What to do
Obtain a baseline ECG and repeat after starting the combination, and correct potassium and magnesium abnormalities. Consider an antidepressant with lower QT liability if the QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Maprotiline?
MediHelp rates the interaction as major. Crizotinib and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes and other serious ventricular arrhythmias. Risk is greater with bradycardia, hypokalemia, hypomagnesemia or underlying heart disease. Crizotinib can also cause bradycardia, which further adds to arrhythmic risk.
How serious is the interaction between Crizotinib and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after starting the combination, and correct potassium and magnesium abnormalities. Consider an antidepressant with lower QT liability if the QTc becomes prolonged.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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