Drug interactions
Crizotinib + Memantine-donepezil
Severity: Major
Crizotinib and Memantine-donepezil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can cause QT prolongation and bradycardia, effects that donepezil may also produce. Combined use may increase the risk of serious arrhythmia and syncope.
What this interaction means in plain words
Crizotinib and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation and heart rate slowing.
What to do
Avoid the combination if an alternative exists. Otherwise monitor the ECG, heart rate and electrolytes regularly, and hold or reduce crizotinib if QTc prolongation or symptomatic bradycardia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Memantine-donepezil?
MediHelp rates the interaction as major. Crizotinib and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib can cause QT prolongation and bradycardia, effects that donepezil may also produce. Combined use may increase the risk of serious arrhythmia and syncope.
How serious is the interaction between Crizotinib and Memantine-donepezil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. Otherwise monitor the ECG, heart rate and electrolytes regularly, and hold or reduce crizotinib if QTc prolongation or symptomatic bradycardia develops.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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