Drug interactions
Crizotinib + Naldemedine
Severity: Minor
Crizotinib and Naldemedine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is a CYP3A4 and P-gp substrate, and crizotinib inhibits both pathways, which may increase naldemedine exposure. This could increase gastrointestinal effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Crizotinib and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by crizotinib reduces naldemedine clearance and increases absorption.
What to do
No dose change is generally required; monitor for abdominal pain, diarrhea and opioid withdrawal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Crizotinib with Naldemedine?
MediHelp rates the interaction as minor. Crizotinib and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is a CYP3A4 and P-gp substrate, and crizotinib inhibits both pathways, which may increase naldemedine exposure. This could increase gastrointestinal effects such as abdominal pain and diarrhea.
How serious is the interaction between Crizotinib and Naldemedine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor for abdominal pain, diarrhea and opioid withdrawal symptoms.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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