Drug interactions
Crizotinib + Pemigatinib
Severity: Moderate
Crizotinib and Pemigatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemigatinib is metabolized by CYP3A4, and crizotinib may increase its exposure. This may increase hyperphosphatemia, ocular toxicity and other adverse effects.
What this interaction means in plain words
Crizotinib and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Pemigatinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4 metabolism of pemigatinib.
What to do
If unavoidable, reduce pemigatinib dose per labeling for moderate CYP3A inhibitors. Monitor phosphate and eye symptoms, and restore the dose after the inhibitor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Pemigatinib
Frequently asked questions
Can I take Crizotinib with Pemigatinib?
MediHelp rates the interaction as moderate. Crizotinib and Pemigatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pemigatinib is metabolized by CYP3A4, and crizotinib may increase its exposure. This may increase hyperphosphatemia, ocular toxicity and other adverse effects.
How serious is the interaction between Crizotinib and Pemigatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If unavoidable, reduce pemigatinib dose per labeling for moderate CYP3A inhibitors. Monitor phosphate and eye symptoms, and restore the dose after the inhibitor is stopped.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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