Drug interactions
Crizotinib + Pexidartinib
Severity: Major
Crizotinib and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is a CYP3A4 substrate, and crizotinib may raise its exposure. Pexidartinib carries a serious hepatotoxicity risk that could be worsened, and crizotinib itself can cause liver injury.
What this interaction means in plain words
Crizotinib and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Pexidartinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4 metabolism of pexidartinib, with overlapping hepatotoxicity.
What to do
Avoid if possible. If used, reduce pexidartinib dose per labeling and monitor liver tests closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Crizotinib with Pexidartinib?
MediHelp rates the interaction as major. Crizotinib and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib is a CYP3A4 substrate, and crizotinib may raise its exposure. Pexidartinib carries a serious hepatotoxicity risk that could be worsened, and crizotinib itself can cause liver injury.
How serious is the interaction between Crizotinib and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used, reduce pexidartinib dose per labeling and monitor liver tests closely.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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