Drug interactions
Crizotinib + Propafenone
Severity: Major
Crizotinib and Propafenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib can prolong the QT interval and cause bradycardia, and propafenone can prolong QRS and QT intervals and is proarrhythmic. Combined use raises the risk of torsades de pointes and other serious ventricular arrhythmias.
What this interaction means in plain words
Crizotinib and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Propafenone belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic QT prolongation and effects on cardiac conduction and heart rate.
What to do
Avoid the combination if possible; otherwise monitor ECG and electrolytes (potassium, magnesium) at baseline and periodically. Reduce or stop crizotinib if QT prolongation becomes significant.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Propafenone?
MediHelp rates the interaction as major. Crizotinib and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib can prolong the QT interval and cause bradycardia, and propafenone can prolong QRS and QT intervals and is proarrhythmic. Combined use raises the risk of torsades de pointes and other serious ventricular arrhythmias.
How serious is the interaction between Crizotinib and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor ECG and electrolytes (potassium, magnesium) at baseline and periodically. Reduce or stop crizotinib if QT prolongation becomes significant.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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