Drug interactions
Crizotinib + Sarecycline
Severity: Minor
Crizotinib and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sarecycline may weakly inhibit P-glycoprotein, theoretically raising crizotinib levels. Clinical significance is likely small at usual acne doses.
What this interaction means in plain words
Crizotinib and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Sarecycline belongs to Anti Bacterial.
Why it happens
Possible P-glycoprotein inhibition by sarecycline reducing crizotinib efflux.
What to do
No dose change is needed; monitor for crizotinib adverse effects such as nausea, visual changes and elevated liver enzymes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Crizotinib with Sarecycline?
MediHelp rates the interaction as minor. Crizotinib and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sarecycline may weakly inhibit P-glycoprotein, theoretically raising crizotinib levels. Clinical significance is likely small at usual acne doses.
How serious is the interaction between Crizotinib and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for crizotinib adverse effects such as nausea, visual changes and elevated liver enzymes.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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