Drug interactions
Crizotinib + Saxagliptin-metformin
Severity: Minor
Crizotinib and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits P-glycoprotein and CYP3A4, which could raise saxagliptin concentrations. Clinical significance is likely modest given saxagliptin's wide safety margin.
What this interaction means in plain words
Crizotinib and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein efflux and CYP3A4 metabolism of saxagliptin.
What to do
No dose change is routinely required. Monitor glucose and watch for saxagliptin adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Crizotinib and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib inhibits P-glycoprotein and CYP3A4, which could raise saxagliptin concentrations. Clinical significance is likely modest given saxagliptin's wide safety margin.
How serious is the interaction between Crizotinib and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required. Monitor glucose and watch for saxagliptin adverse effects.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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