Drug interactions
Crizotinib + Tinidazole
Severity: Minor
Crizotinib and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate inhibitor of CYP3A4 and tinidazole is partly metabolized by this enzyme, so tinidazole levels could rise modestly. Tinidazole has a wide margin of safety, so the effect is expected to be small, though additive gastrointestinal effects and QT prolongation concerns exist with crizotinib.
What this interaction means in plain words
Crizotinib and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Tinidazole belongs to Anti Parasitic.
Why it happens
Crizotinib inhibits CYP3A4, reducing the metabolic clearance of tinidazole.
What to do
No dose adjustment is generally needed; monitor for tinidazole adverse effects such as nausea and neurological symptoms during combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Tinidazole?
MediHelp rates the interaction as minor. Crizotinib and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib is a moderate inhibitor of CYP3A4 and tinidazole is partly metabolized by this enzyme, so tinidazole levels could rise modestly. Tinidazole has a wide margin of safety, so the effect is expected to be small, though additive gastrointestinal effects and QT prolongation concerns exist with crizotinib.
How serious is the interaction between Crizotinib and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for tinidazole adverse effects such as nausea and neurological symptoms during combined use.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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