Drug interactions
Crizotinib + Venetoclax
Severity: Major
Crizotinib and Venetoclax: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and P-gp, both involved in venetoclax disposition, which may raise venetoclax levels. This can increase risks such as neutropenia and tumor lysis syndrome.
What this interaction means in plain words
Crizotinib and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Venetoclax belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4 metabolism and P-gp efflux increases venetoclax exposure.
What to do
Reduce the venetoclax dose by at least 50% if a moderate CYP3A or P-gp inhibitor is needed, and monitor blood counts and tumor lysis markers closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Crizotinib with Venetoclax?
MediHelp rates the interaction as major. Crizotinib and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Crizotinib inhibits CYP3A4 and P-gp, both involved in venetoclax disposition, which may raise venetoclax levels. This can increase risks such as neutropenia and tumor lysis syndrome.
How serious is the interaction between Crizotinib and Venetoclax?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the venetoclax dose by at least 50% if a moderate CYP3A or P-gp inhibitor is needed, and monitor blood counts and tumor lysis markers closely.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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