Drug interactions
Crizotinib + Voclosporin
Severity: Major
Crizotinib and Voclosporin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a CYP3A4 substrate and crizotinib inhibits this enzyme, raising calcineurin inhibitor exposure and risks of nephrotoxicity, hypertension and neurotoxicity. Both drugs can also prolong the QT interval.
What this interaction means in plain words
Crizotinib and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Voclosporin belongs to Miscellaneous.
Why it happens
Crizotinib inhibits CYP3A4 metabolism of voclosporin, with additive QTc effects.
What to do
Reduce the voclosporin dose per labeling for moderate CYP3A4 inhibitors and monitor eGFR, blood pressure, potassium and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Crizotinib with Voclosporin?
MediHelp rates the interaction as major. Crizotinib and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a CYP3A4 substrate and crizotinib inhibits this enzyme, raising calcineurin inhibitor exposure and risks of nephrotoxicity, hypertension and neurotoxicity. Both drugs can also prolong the QT interval.
How serious is the interaction between Crizotinib and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the voclosporin dose per labeling for moderate CYP3A4 inhibitors and monitor eGFR, blood pressure, potassium and ECG.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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