Drug interactions
Crofelemer + Cyclosporin
Severity: Minor
Crofelemer and Cyclosporin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed and inhibits CYP3A4 only in the gut at expected concentrations. A meaningful rise in systemic cyclosporine is unlikely, though a small intestinal effect is possible.
What this interaction means in plain words
Crofelemer and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Cyclosporin belongs to Miscellaneous.
Why it happens
Possible inhibition of intestinal CYP3A4 by crofelemer, with minimal systemic effect.
What to do
No routine adjustment is needed. Check cyclosporine trough levels if toxicity or unexpected levels occur after starting crofelemer.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Cyclosporin?
MediHelp rates the interaction as minor. Crofelemer and Cyclosporin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed and inhibits CYP3A4 only in the gut at expected concentrations. A meaningful rise in systemic cyclosporine is unlikely, though a small intestinal effect is possible.
How serious is the interaction between Crofelemer and Cyclosporin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Check cyclosporine trough levels if toxicity or unexpected levels occur after starting crofelemer.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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