Drug interactions
Crofelemer + Diazepam
Severity: Minor
Crofelemer and Diazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit intestinal CYP3A4 at gut concentrations, but it is minimally absorbed. A clinically meaningful rise in diazepam levels is unlikely.
What this interaction means in plain words
Crofelemer and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Diazepam belongs to Musculoskeletal.
Why it happens
Possible intestinal CYP3A4 inhibition in vitro, with negligible systemic exposure to crofelemer.
What to do
No routine action is needed; be aware of possible increased sedation if the patient seems unusually drowsy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diazepam
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Diazepam?
MediHelp rates the interaction as minor. Crofelemer and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit intestinal CYP3A4 at gut concentrations, but it is minimally absorbed. A clinically meaningful rise in diazepam levels is unlikely.
How serious is the interaction between Crofelemer and Diazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; be aware of possible increased sedation if the patient seems unusually drowsy.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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