Drug interactions
Crofelemer + Erlotinib
Severity: Minor
Crofelemer and Erlotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed but may inhibit CYP3A4 in the gut. A modest increase in erlotinib exposure is theoretically possible.
What this interaction means in plain words
Crofelemer and Erlotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Erlotinib belongs to Oncology.
Why it happens
Intestinal CYP3A4 inhibition by crofelemer could reduce first-pass metabolism of erlotinib.
What to do
No routine adjustment is needed. Monitor for worsening erlotinib adverse effects, particularly diarrhea, and manage as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Erlotinib?
MediHelp rates the interaction as minor. Crofelemer and Erlotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed but may inhibit CYP3A4 in the gut. A modest increase in erlotinib exposure is theoretically possible.
How serious is the interaction between Crofelemer and Erlotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for worsening erlotinib adverse effects, particularly diarrhea, and manage as usual.
What other medicines interact with Erlotinib?
MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.
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