Drug interactions
Crofelemer + Erythromycin
Severity: Minor
Crofelemer and Erythromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer has the potential to inhibit gut CYP3A4 and some transporters, but it is minimally absorbed. A clinically relevant increase in systemic erythromycin exposure is unlikely.
What this interaction means in plain words
Crofelemer and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Erythromycin belongs to Anti Bacterial.
Why it happens
Possible local intestinal CYP3A4 and transporter inhibition by crofelemer, with negligible systemic absorption.
What to do
No routine action is needed. Be aware of the theoretical effect if erythromycin response or tolerability changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Erythromycin?
MediHelp rates the interaction as minor. Crofelemer and Erythromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer has the potential to inhibit gut CYP3A4 and some transporters, but it is minimally absorbed. A clinically relevant increase in systemic erythromycin exposure is unlikely.
How serious is the interaction between Crofelemer and Erythromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Be aware of the theoretical effect if erythromycin response or tolerability changes.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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