Drug interactions
Crofelemer + Metformin-repaglinide
Severity: Minor
Crofelemer and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 in the gut, but it is minimally absorbed so systemic effects are unlikely. A clinically meaningful rise in repaglinide levels is not expected.
What this interaction means in plain words
Crofelemer and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Metformin-repaglinide belongs to Endocrine.
Why it happens
Possible intestinal CYP3A4 inhibition by crofelemer, with negligible systemic exposure.
What to do
No routine action is needed. Be alert for hypoglycemia if the patient reports unexpected symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Metformin-repaglinide?
MediHelp rates the interaction as minor. Crofelemer and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 in the gut, but it is minimally absorbed so systemic effects are unlikely. A clinically meaningful rise in repaglinide levels is not expected.
How serious is the interaction between Crofelemer and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Be alert for hypoglycemia if the patient reports unexpected symptoms.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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