Drug interactions
Crofelemer + Methadone
Severity: Minor
Crofelemer and Methadone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer is minimally absorbed, so systemic interaction with methadone is unlikely. Inhibition of intestinal CYP3A4 is theoretical and clinically significant changes in methadone exposure have not been established.
What this interaction means in plain words
Crofelemer and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Methadone belongs to Musculoskeletal.
Why it happens
Crofelemer may inhibit gut CYP3A4 in vitro, but its minimal systemic absorption makes an effect on methadone unlikely.
What to do
No routine dose change is needed. Be alert to signs of increased opioid effect when starting crofelemer.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Methadone?
MediHelp rates the interaction as minor. Crofelemer and Methadone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer is minimally absorbed, so systemic interaction with methadone is unlikely. Inhibition of intestinal CYP3A4 is theoretical and clinically significant changes in methadone exposure have not been established.
How serious is the interaction between Crofelemer and Methadone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Be alert to signs of increased opioid effect when starting crofelemer.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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