Drug interactions
Cyanocobalamin + Esomeprazole
Severity: Minor
Cyanocobalamin and Esomeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term acid suppression reduces release of food-bound vitamin B12 and may lower B12 status. Oral crystalline cyanocobalamin is less dependent on gastric acid, so the effect is smaller than for dietary B12.
What this interaction means in plain words
Cyanocobalamin and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyanocobalamin belongs to Miscellaneous; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Reduced gastric acid impairs liberation of protein-bound vitamin B12 for absorption.
What to do
Monitor B12 levels in long-term PPI users, particularly older or at-risk patients. Supplement if deficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Cyanocobalamin
Frequently asked questions
Can I take Cyanocobalamin with Esomeprazole?
MediHelp rates the interaction as minor. Cyanocobalamin and Esomeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term acid suppression reduces release of food-bound vitamin B12 and may lower B12 status. Oral crystalline cyanocobalamin is less dependent on gastric acid, so the effect is smaller than for dietary B12.
How serious is the interaction between Cyanocobalamin and Esomeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor B12 levels in long-term PPI users, particularly older or at-risk patients. Supplement if deficient.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
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