Drug interactions
Cyclizine + Desflurane
Severity: Moderate
Cyclizine and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine and can add to the central nervous system depression produced by inhaled anesthetics. This may deepen anesthesia, delay emergence and prolong recovery sedation.
What this interaction means in plain words
Cyclizine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Desflurane belongs to Central Nervous System.
Why it happens
Additive central nervous system depression from H1-antagonist sedation and volatile anesthetic effect.
What to do
Titrate desflurane concentration to depth-of-anesthesia monitoring when cyclizine has been given pre- or perioperatively. Observe closely for delayed emergence and respiratory depression in recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Desflurane?
MediHelp rates the interaction as moderate. Cyclizine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine and can add to the central nervous system depression produced by inhaled anesthetics. This may deepen anesthesia, delay emergence and prolong recovery sedation.
How serious is the interaction between Cyclizine and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate desflurane concentration to depth-of-anesthesia monitoring when cyclizine has been given pre- or perioperatively. Observe closely for delayed emergence and respiratory depression in recovery.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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