Drug interactions
Cyclizine + Dexchlorpheniramine
Severity: Moderate
Cyclizine and Dexchlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating first-generation antihistamines with anticholinergic activity. Taking them together increases drowsiness, impaired psychomotor performance and anticholinergic effects such as dry mouth and urinary retention.
What this interaction means in plain words
Cyclizine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Dexchlorpheniramine belongs to Respiratory.
Why it happens
Additive central H1-receptor blockade and muscarinic antagonism.
What to do
Avoid combining two sedating antihistamines where possible. If both are needed, counsel on driving and machinery and monitor for excessive sedation and anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Cyclizine with Dexchlorpheniramine?
MediHelp rates the interaction as moderate. Cyclizine and Dexchlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating first-generation antihistamines with anticholinergic activity. Taking them together increases drowsiness, impaired psychomotor performance and anticholinergic effects such as dry mouth and urinary retention.
How serious is the interaction between Cyclizine and Dexchlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two sedating antihistamines where possible. If both are needed, counsel on driving and machinery and monitor for excessive sedation and anticholinergic effects.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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