Drug interactions
Cyclizine + Dexmedetomidine
Severity: Moderate
Cyclizine and Dexmedetomidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine has sedative and anticholinergic properties that can add to dexmedetomidine sedation. This may cause oversedation and impaired alertness.
What this interaction means in plain words
Cyclizine and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Dexmedetomidine belongs to Central Nervous System.
Why it happens
Additive CNS depression through alpha-2 agonism and central H1 antagonism.
What to do
Monitor sedation level and lower the dexmedetomidine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexmedetomidine
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Dexmedetomidine?
MediHelp rates the interaction as moderate. Cyclizine and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine has sedative and anticholinergic properties that can add to dexmedetomidine sedation. This may cause oversedation and impaired alertness.
How serious is the interaction between Cyclizine and Dexmedetomidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and lower the dexmedetomidine dose if needed.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Dextromoramide. The full list is on the Dexmedetomidine page.
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