Drug interactions
Cyclizine + Etomidate
Severity: Moderate
Cyclizine and Etomidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etomidate is an intravenous anaesthetic induction agent, and a sedating antihistamine such as cyclizine may deepen or prolong CNS depression. Cyclizine is often given perioperatively as an antiemetic, so this is usually manageable.
What this interaction means in plain words
Cyclizine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Etomidate belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and central H1 blockade.
What to do
Titrate anaesthetic doses to effect and monitor sedation and ventilation, including during recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Etomidate
- Alprazolam + Etomidate Moderate
- Amitriptyline + Etomidate Moderate
- Amobarbital + Etomidate Moderate
- Azelastine + Etomidate Moderate
- Baclofen + Etomidate Moderate
- Brompheniramine + Etomidate Moderate
Frequently asked questions
Can I take Cyclizine with Etomidate?
MediHelp rates the interaction as moderate. Cyclizine and Etomidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etomidate is an intravenous anaesthetic induction agent, and a sedating antihistamine such as cyclizine may deepen or prolong CNS depression. Cyclizine is often given perioperatively as an antiemetic, so this is usually manageable.
How serious is the interaction between Cyclizine and Etomidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate anaesthetic doses to effect and monitor sedation and ventilation, including during recovery.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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