Drug interactions
Cyclizine + Fluphenazine
Severity: Moderate
Cyclizine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine with anticholinergic properties, and combined with fluphenazine it can increase drowsiness and anticholinergic effects such as dry mouth, constipation, urinary retention and confusion. Anticholinergics may also reduce antipsychotic absorption, and the combination may worsen heat intolerance.
What this interaction means in plain words
Cyclizine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive anticholinergic effects.
What to do
Monitor for oversedation and anticholinergic toxicity, particularly in older patients. Consider a non-anticholinergic antiemetic such as ondansetron, bearing in mind its QT effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Fluphenazine?
MediHelp rates the interaction as moderate. Cyclizine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine with anticholinergic properties, and combined with fluphenazine it can increase drowsiness and anticholinergic effects such as dry mouth, constipation, urinary retention and confusion. Anticholinergics may also reduce antipsychotic absorption, and the combination may worsen heat intolerance.
How serious is the interaction between Cyclizine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity, particularly in older patients. Consider a non-anticholinergic antiemetic such as ondansetron, bearing in mind its QT effect.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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