Drug interactions
Cyclizine + Haloperidol
Severity: Moderate
Cyclizine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine with anticholinergic effects, so with haloperidol it can increase drowsiness and anticholinergic effects such as dry mouth, constipation and confusion. Both are also used as antiemetics, and the combination adds little benefit.
What this interaction means in plain words
Cyclizine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Haloperidol belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Monitor sedation and anticholinergic effects, especially in elderly patients. Consider an antiemetic with a different mechanism if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Haloperidol?
MediHelp rates the interaction as moderate. Cyclizine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine with anticholinergic effects, so with haloperidol it can increase drowsiness and anticholinergic effects such as dry mouth, constipation and confusion. Both are also used as antiemetics, and the combination adds little benefit.
How serious is the interaction between Cyclizine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and anticholinergic effects, especially in elderly patients. Consider an antiemetic with a different mechanism if symptoms occur.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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