Drug interactions
Cyclizine + Hydromorphone
Severity: Moderate
Cyclizine and Hydromorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine antiemetic often given with opioids, and it increases drowsiness and may cause anticholinergic effects. The combination is common and usually manageable.
What this interaction means in plain words
Cyclizine and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Hydromorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor sedation and anticholinergic effects such as constipation and urinary retention. Reduce doses if drowsiness is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Hydromorphone?
MediHelp rates the interaction as moderate. Cyclizine and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine antiemetic often given with opioids, and it increases drowsiness and may cause anticholinergic effects. The combination is common and usually manageable.
How serious is the interaction between Cyclizine and Hydromorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and anticholinergic effects such as constipation and urinary retention. Reduce doses if drowsiness is excessive.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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