Drug interactions
Cyclizine + Hydroxyzine
Severity: Moderate
Cyclizine and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating H1 antihistamines with central depressant and anticholinergic properties. Taken together they can cause excessive drowsiness, impaired psychomotor performance and additive anticholinergic effects such as dry mouth, urinary retention and confusion, especially in older adults.
What this interaction means in plain words
Cyclizine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Hydroxyzine belongs to Respiratory.
Why it happens
Additive central H1-receptor blockade and muscarinic antagonism.
What to do
Avoid combining two sedating antihistamines where possible and counsel patients not to drive or operate machinery. Use the lowest effective doses and monitor older patients for confusion and anticholinergic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Cyclizine with Hydroxyzine?
MediHelp rates the interaction as moderate. Cyclizine and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating H1 antihistamines with central depressant and anticholinergic properties. Taken together they can cause excessive drowsiness, impaired psychomotor performance and additive anticholinergic effects such as dry mouth, urinary retention and confusion, especially in older adults.
How serious is the interaction between Cyclizine and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two sedating antihistamines where possible and counsel patients not to drive or operate machinery. Use the lowest effective doses and monitor older patients for confusion and anticholinergic toxicity.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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