Drug interactions
Cyclizine + Iloperidone
Severity: Moderate
Cyclizine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation and have anticholinergic or antihistaminic activity, so combined use increases drowsiness, dizziness and anticholinergic effects. Iloperidone also prolongs the QT interval and orthostatic hypotension may be worsened.
What this interaction means in plain words
Cyclizine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Iloperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression, antimuscarinic and alpha-adrenergic/histaminergic effects.
What to do
Monitor sedation, blood pressure and anticholinergic symptoms, and avoid driving until tolerance is established. Consider an alternative antiemetic in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Cyclizine with Iloperidone?
MediHelp rates the interaction as moderate. Cyclizine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation and have anticholinergic or antihistaminic activity, so combined use increases drowsiness, dizziness and anticholinergic effects. Iloperidone also prolongs the QT interval and orthostatic hypotension may be worsened.
How serious is the interaction between Cyclizine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and anticholinergic symptoms, and avoid driving until tolerance is established. Consider an alternative antiemetic in patients with QT risk factors.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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