Drug interactions
Cyclizine + Perphenazine
Severity: Moderate
Cyclizine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and anticholinergic, so combined use can intensify drowsiness, dry mouth, urinary retention, constipation and confusion. Anticholinergic effects may also slightly reduce oral perphenazine absorption.
What this interaction means in plain words
Cyclizine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and muscarinic blockade, with possible reduced gastrointestinal absorption.
What to do
Counsel about sedation and monitor for anticholinergic toxicity, especially in older adults. Use an alternative antiemetic with less anticholinergic activity if problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Perphenazine?
MediHelp rates the interaction as moderate. Cyclizine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and anticholinergic, so combined use can intensify drowsiness, dry mouth, urinary retention, constipation and confusion. Anticholinergic effects may also slightly reduce oral perphenazine absorption.
How serious is the interaction between Cyclizine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about sedation and monitor for anticholinergic toxicity, especially in older adults. Use an alternative antiemetic with less anticholinergic activity if problems arise.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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