Drug interactions
Cyclizine + Phentermine
Severity: Minor
Cyclizine and Phentermine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine is a sympathomimetic stimulant and cyclizine is a sedating antihistamine with anticholinergic action. Their effects partly oppose one another, and both can raise heart rate, so the net effect is unpredictable.
What this interaction means in plain words
Cyclizine and Phentermine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclizine belongs to Respiratory; Phentermine belongs to Central Nervous System.
Why it happens
Opposing CNS effects and possible additive tachycardia; no clearly established mechanism.
What to do
No dose change is usually needed; monitor heart rate, blood pressure, and sedation or insomnia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Cyclizine with Phentermine?
MediHelp rates the interaction as minor. Cyclizine and Phentermine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phentermine is a sympathomimetic stimulant and cyclizine is a sedating antihistamine with anticholinergic action. Their effects partly oppose one another, and both can raise heart rate, so the net effect is unpredictable.
How serious is the interaction between Cyclizine and Phentermine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor heart rate, blood pressure, and sedation or insomnia.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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